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Higher Caffeine consumption has been associated with reduced risk of Parkinson's disease, and with a more benign progression of motor and non-motor symptoms. An observational cohort study investigat ...


Orthostatic hypotension is increasingly reported as a risk factor for development of late-stage disease features in Parkinson disease. Less is known about its significance in individuals with early Pa ...


Creatine is an antioxidant agent that has shown neuroprotective effects in animal models of Parkinson's disease. Creatine was selected by the National Institute of Neurological Disorders and Stroke ( ...


The first transplantation of stem cells in patients with Parkinson's disease is almost within reach. However, it remains a challenge for researchers to control stem cells accurately in the lab in orde ...


Many patients with Parkinson's disease develop mild cognitive impairment ( MCI ) or dementia. Identifying biomarkers for cognitive impairment could be instrumental in facilitating both early diagnosis ...


Prostate cancer growth and progression may be linked to neurogenesis and to medical anti- Parkinson treatment, but results are inconclusive. Therefore, researchers have examined the association betwee ...


Multiple sclerosis is an autoimmune inflammatory neurological disease with complex aetiology where the causes are not completely known. The main aim of this thesis was to investigate the influence o ...


Immunogenicity of biopharmaceutical products in multiple sclerosis is a frequent side effect which has a multifactorial etiology. Researchers have assessed associations between anti-drug antibody ...


New disease-modifying treatment strategies in multiple sclerosis offer possibilities for individualised treatment. In a study, researchers evaluated patient-reported outcome measures before and afte ...


Verubecestat is an investigational small molecule inhibitor of the enzyme beta-site amyloid precursor protein cleaving enzyme 1 ( BACE1 ) for the potential treatment of Alzheimer’s disease. A resear ...


New efficacy data for investigational Cladribine tablets were presented at the 32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis ( ECTRIMS ), in London. The fi ...


New results from the REGAIN study, a global, placebo-controlled phase 3 registration trial of Eculizumab ( Soliris ) in patients with refractory generalized myasthenia gravis ( gMG ), were presented a ...


A reduction of cardiovascular events has been reported in phase 2 and 3 trials of the proprotein convertase subtilisin kexin 9 ( PCSK9 ) inhibitors Alirocumab and Evolocumab. Researchers have inve ...


New research from researchers based at The Westmead Institute in Sydney has drawn a link between the genetic and environmental circumstances of multiple sclerosis, which affects 2.1 million people wor ...


Traumatic brain injury with a loss of consciousness may be associated with later development of Parkinson's disease but not Alzheimer's disease or incident dementia, according to a study conducted at ...


The results from the phase 2 SYNERGY study evaluating Opicinumab ( anti-LINGO-1 ), an investigational, fully human monoclonal antibody being developed as a potential neuroreparative therapy in people ...


The pathogenesis of rosacea is unclear, but increased matrix metalloproteinase target tissue activity appears to play an important role. Parkinson disease and other neurodegenerative disorders also di ...


Northwestern Medicine researchers have discovered a new cause of Parkinson's disease, mutations in a gene called TMEM230. This appears to be the third gene definitively linked to confirmed cases of th ...


A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related factor 2 ( Nrf2 ) / antioxidant response element signaling, which regulates expression of antioxidant, anti- ...


Runs of premature atrial complexes ( PACs ) are common in stroke patients and perceived to be clinically insignificant, but their prognostic significance is unclear. A study has investigated the ass ...


A study has evaluated the efficacy and tolerability of intravenous Lacosamide ( LCM-iv ) under routine conditions in daily clinical practice as a prospective registry. Patients with any type of sei ...


Few studies have systematically investigated insomnia in adults with epilepsy. Researchers have performed a prospective cross-sectional investigation of the prevalence, severity, and comorbidities ...


White matter is diffusely altered in tuberous sclerosis complex ( TSC ), and these alterations appear to be more evident in subjects with a more severe neurologic phenotype. However, little is known ...


Adipokines, especially leptin and adiponectin, have gained increasing importance in pathophysiology of various neurological diseases including epilepsy. There are experimental data suggesting a role ...


The aim of a study was to evaluate the efficacy and safety of the new antiepileptic drug Brivaracetam ( Briviact ) as add-on treatment for drug-resistant partial epilepsy using meta-analytical techniq ...


A new way of using MRI scanners to look for evidence of multiple sclerosis in the brain has been successfully tested by researchers at The University of Nottingham and Nottingham University Hospitals ...


Men who have high levels of urate, also known as uric acid, in their blood may be less likely to develop Parkinson’s disease, according to a study published in the Neurology, the medical journal of th ...


Autonomic dysfunction frequently occurs in the context of Parkinson disease ( PD ) and may precede onset of motor symptoms. Limited data exist on the prospective association of heart rate variability ...


The use of statins may not be associated with lowering risk for Parkinson's disease ( PD ), according to a new study led by researchers at Penn State College of Medicine and National Institute of Envi ...


Brivaracetam ( UCB 34714; Briviact ) is an add-on treatment for adult patients with partial seizures. Similar to Levetiracetam ( Keppra ), Brivaracetam acts as a high-affinity ligand of the synaptic v ...


The objective of a study was to reach consensus among physicians treating patients with Parkinson's disease ( PD ) regarding key patient characteristics that indicate transition to advanced PD ( APD ) ...


The use of Cannabis with higher delta9-tetrahydrocannabinol content has been associated with greater risk, and earlier onset, of psychosis. However, the effect of Cannabis potency on brain morphology ...


The hepatitis C virus may be associated with an increased risk of developing Parkinson’s disease, according to a study published in the Neurology, the medical journal of the American Academy of Neurol ...


Researchers from the University of Sheffield in collaboration with researchers from the University of York have discovered a drug which has already been in use for decades to treat liver disease. The ...


New results from a prespecified interim analysis of PRIME, the phase 1b placebo-controlled study of Aducanumab in patients with prodromal or mild Alzheimer’s disease, were presented at the Alzheimer’s ...


New results from a 684-subject phase 2b clinical trial evaluating RVT-101, as an adjunctive therapy to Donepezil in patients with mild-to-moderate Alzheimer's disease, were presented at the 2015 Alzhe ...


Multiple sclerosis ( MS ) is a chronic disabling disease of the central nervous system ( CNS ), affecting more than 2 million people worldwide. The disease usually starts in early adulthood, but the ...


Therapeutic repair of myelin disorders may be limited by the relatively slow rate of human oligodendrocyte differentiation. To identify appropriate pharmacological targets with which to accelerate ...


Roche has announced positive results from two pivotal studies evaluating the investigational medicine Ocrelizumab compared with Interferon beta-1a ( Rebif ), a standard-of-care therapy, in people with ...


The first non-vitamin K antagonist oral anticoagulant ( NOAC ) introduced to the market in Japan was Dabigatran ( Pradaxa ) in March 2011, and three more NOACs, Rivaroxaban ( Xarelto ), Apixaban ( Eli ...


Although multiple sclerosis is thought to represent an excessive and inappropriate immune response to several central nervous system ( CNS ) autoantigens, increasing evidence also suggests that multip ...


Multiple sclerosis is triggered by self-reactive T cells that successfully infiltrate the brain and spinal cord where they launch an aggressive autoimmune attack against myelin. Over time, the resulti ...


Modern scientific understanding has considered multiple sclerosis to be a disease controlled by the T cell, a type of white blood cell. Research has shown that in multiple sclerosis, T cells inappropr ...


The phase 3 ASCEND study investigating Natalizumab ( Tysabri ) in the treatment of secondary progressive multiple sclerosis ( SPMS ) did not achieve its primary and secondary endpoints. During the stu ...


The purpose was to report the effects of delayed-release Dimethyl fumarate ( DMF; also known as gastro-resistant DMF ) on the number of relapses requiring intravenous ( IV ) steroids and multiple scle ...


Uric acid may lessen women’s disability after stroke, according to new research published in Stroke, journal of American Heart Association ( AHA ). High levels of Uric acid can lead to kidney ston ...


Researchers have analyzed the evolution of non-motor symptoms and patients’ and neurologists’ clinical global impression ( CGI ) in advanced Parkinson's disease patients treated with Levodopa–Carbidop ...


Extensive published evidence supports the use of subcutaneously-administered Apomorphine as an effective therapy for Parkinson's disease ( PD ) but to date no consensus recommendations have been avail ...


A study has compared the effectiveness ( percentage of change in daily ON, OFF and dyskinesia times ) and tolerability of Levodopa-Carbidopa intestinal gel ( LCIG; Duodopa; Duopa ) in patients with Pa ...


The aim of a study was to compare the safety and efficacy of Botulinum toxin type-A ( BTX-A ) versus anticholinergic therapy as Biperiden HCl in the treatment of cervical dystonia patients. After f ...