Neurology News

Patients with multiple sclerosis and age-related vascular differences

The aim of a study was to analyze morphological and functional aspects of cerebral veins by means of ecocolor- Doppler in young ( i.e., less than or equal to 30 years old ) and older ( i.e., greater t ...
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PPAR-gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack

Peroxisome proliferator-activated receptor gamma ( PPAR-gamma ) agonists are insulin-sensitising drugs used for the treatment of insulin resistance. In addition to lowing glucose in diabetes, these dr ...
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Glioblastoma: Bevacizumab added to initial treatment doesn't improve overall survival

Glioblastoma ( GBM ) is the most common primary malignant adult brain tumor and, despite treatment advances in recent years, the average survival of patients enrolled in clinical trials is less than 1 ...
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Antidepressant: Citalopram in treating Alzheimer's agitation

The antidepressant drug Citalopram ( Celexa, Cipramil, Seropram ), significantly relieved agitation in a group of patients with Alzheimer's disease. In lower doses than those tested, the drug might be ...
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Stroke: ambulance Magnesium treatment does not improve outcome

Giving intravenous Magnesium to stroke patients soon after the start of symptoms, in an attempt to protect brain cells deprived of oxygen, failed to improve stroke-related disability 3 months later, a ...
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Current perspectives on chronic cerebrospinal venous insufficiency

Chronic cerebrospinal venous insufficiency ( CCSVI ) was initially defined as a clinical syndrome comprising stenoses of the internal jugular and/or azygos veins, characterized by collateral venous ou ...
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Mild-to-moderate Alzheimer's disease: Solanezumab, a humanized monoclonal antibody that binds amyloid, has failed to improve cognition or functional ability

Alzheimer's disease is characterized by amyloid-beta plaques, neurofibrillary tangles, gliosis, and neuronal loss. Solanezumab, a humanized monoclonal antibody, preferentially binds soluble forms of a ...
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Psychiatric comorbidity plays an important part in the premature mortality in epilepsy

Epilepsy is associated with high rates of premature mortality, but the contribution of psychiatric comorbidity is uncertain. A study has assessed the prevalence and risks of premature mortality from e ...
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Increasing prevalence of Alzheimer's disease and other forms of dementia in China between 1990 and 2010

China is increasingly facing the challenge of control of the growing burden of non-communicable diseases. Researchers have assessed the epidemiology of Alzheimer's disease and other forms of dementia ...
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Daclizumab HYP may offer an additional treatment option for relapsing-remitting multiple sclerosis

Daclizumab, a humanised monoclonal antibody, modulates interleukin-2 signalling by blocking the alpha subunit ( CD25 ) of the interleukin-2 receptor.Researchers have assessed whether Daclizumab high-y ...
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Tasimelteon for the treatment of non-24-hour-disorder in the totally blind individuals

The Food and Drug Administration's ( FDA ) Peripheral and Central Nervous System Drugs Advisory Committee ( Advisory Committee ) has voted overwhelmingly to recommend the approval of New Drug Applicat ...
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Aspirin associated with Clopidogrel reduces the risk of stroke in patients with minor or transient stroke symptoms

Results of a phase III clinical trial has shown that a simple drug regimen of two anti-clotting drugs, Clopidogrel ( Plavix ) and Acetylsalicylic acid ( Aspirin ) lowered the risk of stroke by almost ...
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Possible cause of non-familial Parkinson's disease: two genetic variants, RAB7L1 and LRRK2

Researchers, at Columbia University Medical Center ( CUMC ), have identified a protein trafficking defect within brain cells that may underlie common non-familial forms of Parkinson's disease. The def ...
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MRI-guided focused ultrasound thalamotomy improves essential tremor

Recent advances have enabled delivery of high-intensity focused ultrasound through the intact human cranium with magnetic resonance imaging ( MRI ) guidance. A preliminary study has investigated the u ...
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Recent lacunar stroke: systolic blood pressure target of less than 130 mmHg is likely to be beneficial

Lowering of blood pressure prevents stroke but optimum target levels to prevent recurrent stroke are unknown. Researchers investigated the effects of different blood-pressure targets on the rate of re ...
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Patients who have had a stroke: effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis

Venous thromboembolism is a common, potentially avoidable cause of death and morbidity in patients in hospital, including those with stroke. In surgical patients, intermittent pneumatic compression ( ...
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Patients with spontaneous supratentorial lobar intracerebral haematomas: early surgery better than initial conservative treatment

The balance of risk and benefit from early neurosurgical intervention for conscious patients with superficial lobar intracerebral haemorrhage of 10-100 mL and no intraventricular haemorrhage admitted ...
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Parkinson's disease: integrated multidisciplinary care

Sudden unexpected death in epilepsy ( SUDEP ) is the leading cause of death in people with chronic refractory epilepsy. Very rarely, SUDEP occurs in epilepsy monitoring units, providing highly informa ...
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Alteration of respiratory and cardiac function induced by generalised tonic-clonic seizure may cause cardiac arrest

Sudden unexpected death in epilepsy ( SUDEP ) is the leading cause of death in people with chronic refractory epilepsy. Very rarely, SUDEP occurs in epilepsy monitoring units, providing highly informa ...
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Preclinical Alzheimer's disease linked to future cognitive decline and mortality

New research criteria for preclinical Alzheimer's disease have been proposed, which include stages for cognitively normal individuals with abnormal amyloid markers ( stage 1 ), abnormal amyloid and ne ...
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