Neurology - Neurology Xagena News

Intracerebral hemorrhage versus major ischemic stroke: benefits and risks of lowering blood pressure acutely after stroke

It is often assumed that blood pressure increases acutely after major stroke, resulting in so-called post-stroke hypertension. In view of evidence that the risks and benefits of blood pressure-lowerin ...
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Atacicept increases clinical disease activity in relapsing multiple sclerosis

Depletion of B lymphocytes is associated with suppression of inflammatory activity in multiple sclerosis. A study has assessed the safety and efficacy of Atacicept, a recombinant fusion protein that s ...
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High-risk patients with intracranial artery stenosis: aggressive medical treatment with or without stenting

Early results of the SAMMPRIS ( Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis ) trial has showed that, by 30 days, 33 ( 14.7% ) of 224 patients in ...
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Benefits of treatment with Rasagiline as an add-on to dopamine agonists in Parkinson's disease

Dopamine agonists are often used as first-line monotherapy for the symptomatic control of Parkinson's disease. However, dopamine agonist monotherapy typically becomes inadequate within a few years, at ...
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Refractory partial-onset seizures and secondarily generalized seizures: long-term safety of Perampanel

A study ( Study 307 ) has evaluated safety, tolerability, seizure frequency, and regional variations in treatment responses with the AMPA antagonist, Perampanel ( Fycompa ), in a large extension study ...
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Efficacy and safety of Epidiolex, a Cannabidiol product, in children and young adults with treatment-resistant epilepsy

Preliminary efficacy and safety data on 27 children and young adults with treatment-resistant epilepsy who have been treated with an investigational Cannabidiol ( CBD ) product candidate, Epidiolex, f ...
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ReWalk, the first wearable, motorized device that helps people with paraplegia due to a spinal cord injury to walk

The FDA ( Food and Drug Administration ) has allowed marketing of the first motorized device intended to act as an exoskeleton for people with lower body paralysis ( paraplegia ) due to a spinal cord ...
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Lack of endothelial cells in the internal jugular vein intraluminal obstacles, a further abnormality found in course of chronic cerebrospinal venous insufficiency

Intraluminal defects such as membranes, immobile leaflets of the valves and septa have been described in the internal jugular vein ( IJV ) and classified by a quite recent Consensus among the truncul ...
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Children with partial epilepsy: adjunctive Zonisamide therapy in the long-term treatment

The aim of a phase III, placebo-controlled trial, including an open-label extension, was to investigate the safety / tolerability and efficacy of long-term adjunctive Zonisamide ( Zonegran ) and its i ...
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Multiple sclerosis: Alfacalcidol is safe and effective for treating fatigue

A study has evaluated the effect of Vitamin D analogue, Alfacalcidol, on multiple sclerosis-related fatigue. Fatigue is one of the most common and disabling symptoms of multiple sclerosis, not effi ...
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Relapsing-remitting multiple sclerosis: cognitive functioning and subjective quality of life in patients before and after percutaneous transluminal angioplasty

The uncertainties of the actual etiological basis of multiple sclerosis make it difficult to reach a conclusive statement about the optimal therapeutic management of the disease, which may differ depe ...
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Treatment of advanced Parkinson disease: deep brain stimulation of the globus pallidus versus subthalamic nucleus

Deep brain stimulation ( DBS ) is the surgical procedure of choice for patients with advanced Parkinson disease. The globus pallidus internus ( GPi ) and the subthalamic nucleus ( STN ) are commonly t ...
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Parkinson’s disease: LRRK2 inhibitors slow disease progression in murine model

An enzyme closely associated with genetic forms of Parkinson’s disease appears to play a larger role in its progression than previously thought, according to researchers at the University of Alabama a ...
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Adult patients with Chiari malformation and meurological and neurosurgical treatment

The best surgical tactics in Chiari malformation are not established yet. A group of patients which firstly were treated conservatively and after some period were operated on, was followed up. The ...
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Anti-TNF alpha-induced neuropathies

The aim of the study was to determine the type and frequency of peripheral neuropathy in patients with inflammatory disorders taking anti-TNF alpha agents. Researchers at Lausanne University Hospit ...
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Retinal plaques in Alzheimer’s disease

The aim of a study was to evaluate the existence of pathologic retinal deposits in patients with possible Alzheimer’s disease. Researchers have examined 20 patients with mild cognitive impairment, ...
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Pisa syndrome is a frequent and disabling complication in Parkinson’s disease in the advanced phase

Idiopathic Pisa syndrome in Parkinson’s disease is a rare entity with only sporadic single case descriptions. Therefore, its pathophysiology has been poorly investigated. Researchers have performed ...
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Bariatric surgery associated with various manifestations of the peripheral nervous system

Sleeve gastrectomy is a safe and effective fast growing weight loss surgery option. Nevertheless complications are not rare. Five patients who developed sensorimotor symptoms after sleeve gastrecto ...
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Acute stroke: migraineurs are more susceptible to infarct growth

Epidemiological data have indicated that migraine is an independent stroke risk factor. Recent data suggest that migraine mutations increase brain vulnerability to ischemia via excitatory mechanisms. ...
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Treatment of Huntington’s chorea: pallidal deep brain stimulation

Stereotactic lesions have been occasionally performed in Huntington’s chorea since the dawn of functional stereotactic surgery, however, with modest results. Despite the success of deep brain stimul ...
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